Hypothesis:
Can high doses of Vitamin C protect and repair nerve damage in the brain;
could high doses of Vitamin C protect and repair nerve damage in the spine?
Mega
dosage would mean doses of 50,000 mgs – 100,000 mgs or more.
Delivery
methods preferably by IV or Liposomal.
There is plenty of research from several doctors to warrant the investigation
of mega doses of Vitamin C and its healing ability for a wide variety of
diseases and injuries.
Since neurological diseases are characterized by increased free radical generation and the highest concentrations of Vit C in the body are found in the brain and neuroendocrine tissues, it is suggested that Vit C may change the course of neurological diseases and display potential therapeutic roles.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537779/#:~:text=Since%20neurological%20diseases%20are%20characterized,and%20display%20potential%20therapeutic%20roles.
http://www.mdpi.com/2072-6643/9/7/659/pdf
In 1949 Klenner published in and presented a paper to the American Medical Association detailing the complete cure of 60 out of 60 of his patients with polio using intravenous sodium ascorbate injection[7] Galloway and Seifert cited Klenner's presentation to the AMA in a paper of theirs.[8] Generally, he gave 350 to 700 mg per kilogram body weight per day.
He described giving up to 300,000 milligrams (mg) per day of neutral pH sodium ascorbate. Klenner published 27 medical papers, most about vitamin C applications for over 30 diseases, two about treatment of severe neuropathies including multiple sclerosis using aggressive supplementation].[9] He wrote a 28th paper ca 1980, an unpublished update about MS treatment. It was posthumously summarized by Lendon Smith in the Clinical Guide to the Use of Vitamin C.
Source: http://en.wikipedia.org/wiki/Fred_R._Klenner
Additional source link: http://www.whale.to/m/klenner.html
Here in the below linked paper by Dr. Klenner we have his recommendation of massive doses of vitamins for Myasthenia Gravis disease, Multiple Sclerosis which is similar to Polio, which he cured patients of.
Also outlining the importance of Thiamin Hydrochloride and B Vitamins:
On page 11 of this report he states this:
He
summarized the function of Vitamin C in poliomyelitis:
1. Virus destruction.
2. Dehydrates the brain and the spinal cord safely.
3. Supports and normalized the stressed adrenal glands.
4. It preserves the lining of the central canal and maintains more regular spacing and less crowding of ependymal cells (surface cells of the spinal cord).
“A significant body of evidence suggests that oxidative stress plays an important role in the manifestation of critical illness. Active oxygen species (ROS) induce direct oxidative tissue injury by means of peroxidation of cellular membranes, oxidation of critical enzymatic and structural proteins, and inductions of apoptosis….
The
brain and central nervous system are made up of large amounts of nerve cells. Stanford University's
HOPES Project also notes that Vitamin C, also known as ascorbic acid, is also
very prevalent in parts of the brain in between nerve cells. Studies have shown potential that Vitamin C
can repair and prevent nerve damage.
Stanford University
Read more: http://www.livestrong.com/article/280797-vitamin-c-to-repair-nerve-damage/#ixzz2LjyQfbgj
Another study done by Seattle’s Harborview Medical study administering
Vitamin C:
“In a prospective observational study, all trauma admissions to the HMC surgical ICU had 3 grams of
Conclusion and
Questions:
Perhaps
consultation could be made with doctors currently leading the research and use
of Vitamin C.
Most
of his work over the last ten years has centered on the importance of
maintaining a healthy antioxidant status in the body. His work currently is
focusing on the importance of liposomal technology as a way to optimally
deliver vitamin C, glutathione, and other nutrients into the body orally,
appearing to even surpass the bioavailability seen with the intravenous
administration of these antioxidants.
Since neurological diseases are characterized by increased free radical generation and the highest concentrations of Vit C in the body are found in the brain and neuroendocrine tissues, it is suggested that Vit C may change the course of neurological diseases and display potential therapeutic roles.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537779/#:~:text=Since%20neurological%20diseases%20are%20characterized,and%20display%20potential%20therapeutic%20roles.
http://www.mdpi.com/2072-6643/9/7/659/pdf
Vitamin
C is a cofactor in at least eight enzymatic reactions including several collagen
synthesis reactions…
…Collagen is also
important for the formation of the lining (myelin sheath) around nerves.
Studies on the effect of vitamin C on myelin demonstrate that high doses
stimulate myelin formation and differentiation of schwann cells, which protect
the neurons of the peripheral nervous system.
There appears to be
an important interaction between vitamin E and vitamin C in the brain and
spinal cord. In another study of guinea pigs made deficient in vitamin E alone,
the pigs appeared to be perfectly normal.
But when researchers also removed vitamin C from the animals’ diets,
they developed a progressive ascending paralysis and died within 24 hours.
It appears that even
modest decreases in nervous system vitamin C could accelerate vitamin E
deficiency with significant damage to the spinal cord and brain stem.
Interestingly,
vitamin C has been shown to enhance maturation of the synapse (the connection between two brain
cells), which is something not done by other antioxidants. This all means that vitamin C is
important to how the brain forms and develops.
Because of the high
level of vitamin C in the substantia nigra (a midbrain structure that controls movement,
among other things) and striatum (part of the basal ganglia, which also governs movement), it
may be that vitamin C is involved in Parkinson’s disease.
Vitamin C promotes oligodendrocytes generation and remyelination.
Vitamin C promotes oligodendrocytes generation and remyelination.
PubMed: https://www.ncbi.nlm.nih.gov/pubmed/29423921
Dr. Fred R. Klenner
Dr
Klenner was a leading proponent to mega dosing Vitamin C. From the 1940s on he experimented with the use of mega dosage as a therapy
for a wide range of illnesses, most notably polio. He authored 28 research papers during his
career. He was one of the originators of orthomolecular medicine, but his work
remains largely unaddressed by established medicine.
In 1949 Klenner published in and presented a paper to the American Medical Association detailing the complete cure of 60 out of 60 of his patients with polio using intravenous sodium ascorbate injection[7] Galloway and Seifert cited Klenner's presentation to the AMA in a paper of theirs.[8] Generally, he gave 350 to 700 mg per kilogram body weight per day.
He described giving up to 300,000 milligrams (mg) per day of neutral pH sodium ascorbate. Klenner published 27 medical papers, most about vitamin C applications for over 30 diseases, two about treatment of severe neuropathies including multiple sclerosis using aggressive supplementation].[9] He wrote a 28th paper ca 1980, an unpublished update about MS treatment. It was posthumously summarized by Lendon Smith in the Clinical Guide to the Use of Vitamin C.
Source: http://en.wikipedia.org/wiki/Fred_R._Klenner
Additional source link: http://www.whale.to/m/klenner.html
Here in the below linked paper by Dr. Klenner we have his recommendation of massive doses of vitamins for Myasthenia Gravis disease, Multiple Sclerosis which is similar to Polio, which he cured patients of.
Also outlining the importance of Thiamin Hydrochloride and B Vitamins:
On page 11 of this report he states this:
“…Our diagnosis in this
case is Transverse Myelitis. (200 grams ascorbic acid given IV, in divided
doses, would have saved this patient from paralysis.) She has also received 300mg
ribonucleic acid four times each week.
Note: We don’t want to overlook the
importance placed on Nicotinic Acid that Dr. Klenner employed as well.
And
most importantly, on page 11 of this report:
“In years past, when
we were treating Poliomyelitis successfully
with massive doses of ascorbic acid, we would always follow with an
indefinite timetable, giving the B vitamins for nerve repair.
We see the same results when treating damage to the spinal cord, whether this is due to mechanical trauma, or to the inflammation caused by a virus, any virus.”
There is much more about how he treated MS and the vitamins
used in the full report:
1. Virus destruction.
2. Dehydrates the brain and the spinal cord safely.
3. Supports and normalized the stressed adrenal glands.
4. It preserves the lining of the central canal and maintains more regular spacing and less crowding of ependymal cells (surface cells of the spinal cord).
This report outlines Dr. Klenner’s discovery of the
miraculous uses of Vitamin C on a variable number of illnesses, diseases and
injuries.
Vitamin
C (Ascorbic Acid) has many important functions. It is a powerful oxidizer and when
given in massive amounts; that is, 50 grams to 150 grams, intravenously, for
certain pathological conditions…
Research has shown that during
times of acute illness and traumatic injury the plasma levels of Vitamin C are
depleted.
“A significant body of evidence suggests that oxidative stress plays an important role in the manifestation of critical illness. Active oxygen species (ROS) induce direct oxidative tissue injury by means of peroxidation of cellular membranes, oxidation of critical enzymatic and structural proteins, and inductions of apoptosis….
The
importance of oxidative stress in the early phases of critical illness is
underscored by the relative antioxidant depletion reported in many observations
studies…
For
example, patients admitted to ICU have reduced total antioxidant capacity, with
lower circulating levels of a-tocopherol and serum ascorbate and increased
alveolar fluid levels of oxidized glutathione.”
(This
is a study done by Harborview Medical Center – Seattle)
Stanford University
Read more: http://www.livestrong.com/article/280797-vitamin-c-to-repair-nerve-damage/#ixzz2LjyQfbgj
“In a prospective observational study, all trauma admissions to the HMC surgical ICU had 3 grams of
Vitamin C or 3,000
international units of Vitamin E, divided over three doses per day, started at
the time of admission.
Otherwise, care was
standard and the populations were followed to determine the incidence of ARDS
(acute respiratory distress syndrome), duration in the ICU, mortality and
infectious complications. In addition, we studied BAL samples for evidence of
oxidant injury and cytokine production.
The results show that the treatment with anti-oxidant supplementation
on admission to the surgical ICU produced a 50% reduction in the evidence of
oxidant injury in the BAL solution, along with a 50% reduction in the
production of inflammatory mediators, while having no detrimental effect on the
production of antibacterial mediators of the immune system. Concomitant with
this decrease in intrapulmonary inflammatory response, there was a decrease by
50% in the incidence of ARDS and a significant decrease in length of stay and
ventilator days in these critically ill patients.”
Source: http://www.gluegrant.org/PDFs/maier.pdf
Another Study:
Vitamin C Might Help Treat Multiple Sclerosis Read more from Asian Scientist Magazine at: https://www.asianscientist.com/2018/03/in-the-lab/vitamin-c-myelin-multiple-sclerosis/Recent studies have showed that Vc could also promote somatic cell reprogramming and facilitate the generation of high quality induced pluripotent stem cells (Chen et al., 2013; Esteban et al., 2010). In this study, we demonstrated that Vc could also enhance the differentiation of OPCs to OLs and promote myelin formation both in vitro and in vivo.
Another Study:
Vitamin C Might Help Treat Multiple Sclerosis Read more from Asian Scientist Magazine at: https://www.asianscientist.com/2018/03/in-the-lab/vitamin-c-myelin-multiple-sclerosis/Recent studies have showed that Vc could also promote somatic cell reprogramming and facilitate the generation of high quality induced pluripotent stem cells (Chen et al., 2013; Esteban et al., 2010). In this study, we demonstrated that Vc could also enhance the differentiation of OPCs to OLs and promote myelin formation both in vitro and in vivo.
Traumatic
injury causes depletion of Vitamin C and other anti-oxidants in the body.
High
dose Vitamin C can be anti-inflammatory and is an anti-oxidant and a pro-oxidant.
Since
Vitamin C deficiency has shown to cause paralysis, can mega doses of Vitamin C
be a “healing” agent for the spine and nerves?
If
Harborview Medical Center has such a resounding positive result of
administering Vitamin C to traumatic injury patients admitted to ICU, then why
is it not administered as a “standard protocol” to all trauma patients?
Dr. Thomas
Levy
Dr.
Thomas E. Levy is a board certified cardiologist and he has written six books on health-related issues.
Most of his work has centered on how to restore and/or maintain good health in
the face of the many different forms of toxicity that all of us face, typically
on a daily basis. He no longer has a clinical practice of medicine and cardiology.
Rather, he limits himself to research and writing.
Dr. Stephen Hickey, Ph.D.
Steve
Hickey has a B.A. (math and science) from the Open University, membership of
the Institute of Biology by examination in pharmacology, and is a chartered
biologist and a former member of the British Compute Society. He did research
into ultra-high-resolution computerized tomography (CT) body scanning, leading
the physics team in Europe_s first clinical magnetic resonance (MR) imaging
unit at Manchester Medical School. He has over 100 scientific publications,
covering a variety of disciplines. Currently, he is a member of the biology
department of Staffordshire University.
Andrew W. Saul, Ph.D.,
Dr.
Andrew Saul has over thirty years of experience in natural health education. He
is chairman of the Independent Vitamin Safety Review Panel, editor of the
Orthomolecular Medicine News Service, and assistant editor of the ;Journal of
Orthomolecular Medicine. He is the author of "Doctor Yourself: Natural
Healing that Works. and Fire Your Doctor! How to Be Independently Healthy. His
popular, peer-reviewed, non-commercial natural healing website is
DoctorYourself.com.
Formerly Assistant
Editor of the Journal of Orthomolecular Medicine, is
Editor-in-Chief of the peer-reviewed Orthomolecular
Medicine News Service. He was on the faculty of the State University of New
York for nine years, and taught nutrition, health science and cell biology at
the college level. He has studied in Africa and
Australia
Dr. Robert F. Cathcart III, M.D.
ALLERGY, ENVIRONMENTAL & ORTHOMOLECULAR MEDICINE
127 SECOND STREET, SUITE 4
LOS ALTOS, CALIFORNIA 94022
(650) 949-2822
ALLERGY, ENVIRONMENTAL & ORTHOMOLECULAR MEDICINE
127 SECOND STREET, SUITE 4
LOS ALTOS, CALIFORNIA 94022
(650) 949-2822
Delivery methods preferably by IV or Liposomal.
Liposomal Vitamin C is superior to IV and can be made at home for pennies and causes NO diarrhea. Made with soy lecithin for immediate absorption. “The hydrophilic nature of the lecithin molecule plays an important part in the structure and properties of cell membranes. It is the lipid used in nerve tissue.”
There currently are no medical studies of mega doses of Vitamin C and spinal injury.
Thank you for maintaining and creating this web page. It is life changing news for anyone who finds it and restores real hope to many who have been advised to give up by the medical establishment. We need to break the stranglehold that the AMA has placed on researching and implementing these sorts of treatments, so we can make progress as a society.
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